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Orientational preferences of neighboring helices can drive ER insertion of a marginally hydrophobic transmembrane helix
α-helical integral membrane proteins critically depend on the correct insertion of their transmembrane α-helices into the lipid bilayer for proper folding, yet a surprisingly large fraction of the transmembrane α-helices in multispanning integral membrane proteins are not sufficiently hydrophobic to...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3553544/ https://ncbi.nlm.nih.gov/pubmed/22281052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.12.024 |
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