Murine astrotactins 1 and 2 have a similar membrane topology and mature via endoproteolytic cleavage catalyzed by a signal peptidase

Astrotactin 1 (Astn1) and Astn2 are membrane proteins that function in glial-guided migration, receptor trafficking, and synaptic plasticity in the brain as well as in planar polarity pathways in the skin. Here we used glycosylation mapping and protease protection approaches to map the topologies of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lara, Patricia, Tellgren-Roth, Åsa, Behesti, Hourinaz, Horn, Zachi, Schiller, Nina, Enquist, Karl, Cammenberg, Malin, Liljenström, Amanda, Hatten, Mary E., von Heijne, Gunnar, Nilsson, IngMarie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433051/
https://ncbi.nlm.nih.gov/pubmed/30696770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007093
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