Iterative Design of Emetine-Based Prodrug Targeting Fibroblast Activation Protein (FAP) and Dipeptidyl Peptidase IV DPPIV Using a Tandem Enzymatic Activation Strategy

BACKGROUND. There is an urgent need to develop new agents for treating metastatic prostate cancer to overcome multiple drug resistance to the current standard targeted cancer therapy. Emetine is a highly cytotoxic natural product protein synthesis inhibitor, which is toxic to all cell types. Its cyt...

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Bibliografiska uppgifter
I publikationen:Prostate
Huvudupphovsmän: Akinboye, Emmanuel S., Brennen, W. Nathaniel, Rosen, D. Marc, Bakare, Oladapo, Denmeade, Samuel R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432629/
https://ncbi.nlm.nih.gov/pubmed/26835873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23162
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