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Design, synthesis and evaluation of pH-dependent hydrolysable emetine analogs as treatment for prostate cancer

The N-2′ position of the natural product emetine has been derivatized to thiourea, urea, sulfonamide, dithiocarbamate, carbamate and pH responsive hydrolysable amide analogs. In-vitro studies of these analogs in PC3 and LNCaP prostate cancer cell lines showed that the analogs are generally less cyto...

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Bibliografiske detaljer
Main Authors: Akinboye, Emmanuel S., Rosen, Marc D., Denmeade, Samuel R., Kwabi-Addo, Bernard, Bakare, Oladapo
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654864/
https://ncbi.nlm.nih.gov/pubmed/22867001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300426q
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