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Design, synthesis and evaluation of pH-dependent hydrolysable emetine analogs as treatment for prostate cancer
The N-2′ position of the natural product emetine has been derivatized to thiourea, urea, sulfonamide, dithiocarbamate, carbamate and pH responsive hydrolysable amide analogs. In-vitro studies of these analogs in PC3 and LNCaP prostate cancer cell lines showed that the analogs are generally less cyto...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3654864/ https://ncbi.nlm.nih.gov/pubmed/22867001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300426q |
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