Novel Carbonyl Analogs of Tamoxifen: Design, Synthesis, and Biological Evaluation

Aim of this work was to provide tamoxifen analogs with enhanced estrogen receptor (ER) binding affinity. Hence, several derivatives were prepared using an efficient triarylethylenes synthetic protocol. The novel compounds bioactivity was evaluated through the determination of their receptor binding...

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Bibliografiske detaljer
Udgivet i:Front Chem
Main Authors: Kasiotis, Konstantinos M., Lambrinidis, George, Fokialakis, Nikolas, Tzanetou, Evangelia N., Mikros, Emmanuel, Haroutounian, Serkos A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622936/
https://ncbi.nlm.nih.gov/pubmed/29018796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2017.00071
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