Population Pharmacokinetics of Clozapine and Norclozapine and Switchability Assessment between Brands in Uruguayan Patients with Schizophrenia

Clozapine (CZP) is an atypical antipsychotic agent commonly used in the treatment of schizophrenia. It is metabolized primarily by CYP1A2 enzyme, yielding a pharmacologically active metabolite, norclozapine (NCZP). Significant intra- and interindividual pharmacokinetic (PK) variability for CZP and N...

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Dettagli Bibliografici
Pubblicato in:Biomed Res Int
Autori principali: Olmos, Ismael, Ibarra, Manuel, Vázquez, Marta, Maldonado, Cecilia, Fagiolino, Pietro, Giachetto, Gustavo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431368/
https://ncbi.nlm.nih.gov/pubmed/30956977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3163502
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