Population Pharmacokinetics of Clozapine and Norclozapine and Switchability Assessment between Brands in Uruguayan Patients with Schizophrenia

Clozapine (CZP) is an atypical antipsychotic agent commonly used in the treatment of schizophrenia. It is metabolized primarily by CYP1A2 enzyme, yielding a pharmacologically active metabolite, norclozapine (NCZP). Significant intra- and interindividual pharmacokinetic (PK) variability for CZP and N...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Biomed Res Int
Asıl Yazarlar: Olmos, Ismael, Ibarra, Manuel, Vázquez, Marta, Maldonado, Cecilia, Fagiolino, Pietro, Giachetto, Gustavo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Hindawi 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431368/
https://ncbi.nlm.nih.gov/pubmed/30956977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3163502
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