Steady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients

BACKGROUND: Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady state pharmacokinetics in New Zealand Maori and European patients. METHODS: Clozapine...

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Bibliographic Details
Published in:EBioMedicine
Main Authors: Menkes, David B., Glue, Paul, Gale, Christopher, Lam, Frederic, Hung, Cheung-Tak, Hung, Noelyn
Format: Artigo
Language:Inglês
Published: Elsevier 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828556/
https://ncbi.nlm.nih.gov/pubmed/29254680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.11.030
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