Steady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients

BACKGROUND: Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady state pharmacokinetics in New Zealand Maori and European patients. METHODS: Clozapine...

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Publicat a:EBioMedicine
Autors principals: Menkes, David B., Glue, Paul, Gale, Christopher, Lam, Frederic, Hung, Cheung-Tak, Hung, Noelyn
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828556/
https://ncbi.nlm.nih.gov/pubmed/29254680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.11.030
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