Population pharmacokinetics of clozapine and its primary metabolite norclozapine in Chinese patients with schizophrenia

AIM: To develop a combined population pharmacokinetic model (PPK) to assess the magnitude and variability of exposure to both clozapine and its primary metabolite norclozapine in Chinese patients with refractory schizophrenia via sparse sampling with a focus on the effects of covariates on the pharm...

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Detalhes bibliográficos
Main Authors: Li, Li-jun, Shang, De-wei, Li, Wen-biao, Guo, Wei, Wang, Xi-pei, Ren, Yu-peng, Li, An-ning, Fu, Pei-xin, Ji, Shuang-min, Lu, Wei, Wang, Chuan-yue
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011352/
https://ncbi.nlm.nih.gov/pubmed/22820910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.71
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