Population pharmacokinetics of clozapine and its primary metabolite norclozapine in Chinese patients with schizophrenia

AIM: To develop a combined population pharmacokinetic model (PPK) to assess the magnitude and variability of exposure to both clozapine and its primary metabolite norclozapine in Chinese patients with refractory schizophrenia via sparse sampling with a focus on the effects of covariates on the pharm...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Li, Li-jun, Shang, De-wei, Li, Wen-biao, Guo, Wei, Wang, Xi-pei, Ren, Yu-peng, Li, An-ning, Fu, Pei-xin, Ji, Shuang-min, Lu, Wei, Wang, Chuan-yue
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2012
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011352/
https://ncbi.nlm.nih.gov/pubmed/22820910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.71
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