Population pharmacokinetics of clozapine and its primary metabolite norclozapine in Chinese patients with schizophrenia

AIM: To develop a combined population pharmacokinetic model (PPK) to assess the magnitude and variability of exposure to both clozapine and its primary metabolite norclozapine in Chinese patients with refractory schizophrenia via sparse sampling with a focus on the effects of covariates on the pharm...

詳細記述

保存先:
書誌詳細
主要な著者: Li, Li-jun, Shang, De-wei, Li, Wen-biao, Guo, Wei, Wang, Xi-pei, Ren, Yu-peng, Li, An-ning, Fu, Pei-xin, Ji, Shuang-min, Lu, Wei, Wang, Chuan-yue
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2012
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011352/
https://ncbi.nlm.nih.gov/pubmed/22820910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.71
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