Population pharmacokinetics of clozapine and its primary metabolite norclozapine in Chinese patients with schizophrenia

AIM: To develop a combined population pharmacokinetic model (PPK) to assess the magnitude and variability of exposure to both clozapine and its primary metabolite norclozapine in Chinese patients with refractory schizophrenia via sparse sampling with a focus on the effects of covariates on the pharm...

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Autors principals: Li, Li-jun, Shang, De-wei, Li, Wen-biao, Guo, Wei, Wang, Xi-pei, Ren, Yu-peng, Li, An-ning, Fu, Pei-xin, Ji, Shuang-min, Lu, Wei, Wang, Chuan-yue
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011352/
https://ncbi.nlm.nih.gov/pubmed/22820910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.71
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