Population Pharmacokinetics of Clozapine and Norclozapine and Switchability Assessment between Brands in Uruguayan Patients with Schizophrenia

Clozapine (CZP) is an atypical antipsychotic agent commonly used in the treatment of schizophrenia. It is metabolized primarily by CYP1A2 enzyme, yielding a pharmacologically active metabolite, norclozapine (NCZP). Significant intra- and interindividual pharmacokinetic (PK) variability for CZP and N...

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Vydáno v:Biomed Res Int
Hlavní autoři: Olmos, Ismael, Ibarra, Manuel, Vázquez, Marta, Maldonado, Cecilia, Fagiolino, Pietro, Giachetto, Gustavo
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431368/
https://ncbi.nlm.nih.gov/pubmed/30956977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3163502
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