Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects

Phenytoin (PHT) oxidative route leads to its main metabolite p-hydroxyphenytoin (p-HPPH), by means of CYP2C9 and CYP2C19. Formation of p-HPPH proceeds via a reactive arene-oxide intermediate. This intermediate can also be converted into PHT dihydrodiol by microsomal epoxide hydrolase (EPHX). The thr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Pharmaceuticals (Basel)
Main Authors: Guevara, Natalia, Maldonado, Cecilia, Uría, Manuel, González, Raquel, Ibarra, Manuel, Alvariza, Silvana, Carozzi, Antonella, Azambuja, Carlos, Fagiolino, Pietro, Vázquez, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620617/
https://ncbi.nlm.nih.gov/pubmed/28820457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph10030073
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados