Steady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients

BACKGROUND: Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady state pharmacokinetics in New Zealand Maori and European patients. METHODS: Clozapine...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Menkes, David B., Glue, Paul, Gale, Christopher, Lam, Frederic, Hung, Cheung-Tak, Hung, Noelyn
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828556/
https://ncbi.nlm.nih.gov/pubmed/29254680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.11.030
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