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Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway

The Ras-Erk (extracellular signal-regulated kinase) pathway encodes information in its dynamics; the duration and frequency of Erk activity can specify distinct cell fates. To enable dynamic encoding, temporal information must be accurately transmitted from the plasma membrane to the nucleus. We use...

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Bibliografiske detaljer
Udgivet i:Science
Main Authors: Bugaj, L. J., Sabnis, A. J., Mitchell, A., Garbarino, J. E., Toettcher, J. E., Bivona, T. G., Lim, W. A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430110/
https://ncbi.nlm.nih.gov/pubmed/30166458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao3048
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