Molecular signaling in multiple myeloma: association of RAS/RAF mutations and MEK/ERK pathway activation

Multiple myeloma (MM) is a plasma cell malignancy that is still considered to be incurable in most cases. A dominant mutation cluster has been identified in RAS/RAF genes, emphasizing the potential significance of RAS/RAF/MEK/ERK signaling as a therapeutic target. As yet, however, the clinical relev...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Xu, J, Pfarr, N, Endris, V, Mai, E K, Md Hanafiah, N H, Lehners, N, Penzel, R, Weichert, W, Ho, A D, Schirmacher, P, Goldschmidt, H, Andrulis, M, Raab, M S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523069/
https://ncbi.nlm.nih.gov/pubmed/28504689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.36
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