CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response

Relapsed acute lymphoblastic leukemia is the most common cause of cancer-related mortality in young people and new therapeutic strategies are needed to improve outcome. Recent studies have shown that heterozygous inactivating mutations in the histone acetyl transferase, CREBBP, are particularly freq...

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Bibliografiset tiedot
Julkaisussa:Haematologica
Päätekijät: Dixon, Zach A., Nicholson, Lindsay, Zeppetzauer, Martin, Matheson, Elizabeth, Sinclair, Paul, Harrison, Christine J., Irving, Julie A.E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Ferrata Storti Foundation 2017
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395114/
https://ncbi.nlm.nih.gov/pubmed/27979926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.145177
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