The Impact of the C-Terminal Region on the Interaction of Topoisomerase II Alpha with Mitotic Chromatin

Type II topoisomerase enzymes are essential for resolving DNA topology problems arising through various aspects of DNA metabolism. In vertebrates two isoforms are present, one of which (TOP2A) accumulates on chromatin during mitosis. Moreover, TOP2A targets the mitotic centromere during prophase, pe...

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I publikationen:Int J Mol Sci
Huvudupphovsmän: Antoniou-Kourounioti, Melissa, Mimmack, Michael L., Porter, Andrew C.G., Farr, Christine J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429393/
https://ncbi.nlm.nih.gov/pubmed/30871006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20051238
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