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Automated cryo-EM structure refinement using correlation-driven molecular dynamics

We present a correlation-driven molecular dynamics (CDMD) method for automated refinement of atomistic models into cryo-electron microscopy (cryo-EM) maps at resolutions ranging from near-atomic to subnanometer. It utilizes a chemically accurate force field and thermodynamic sampling to improve the...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Igaev, Maxim, Kutzner, Carsten, Bock, Lars V, Vaiana, Andrea C, Grubmüller, Helmut
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424565/
https://ncbi.nlm.nih.gov/pubmed/30829573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43542
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