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A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest
Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in Streptococcus sanguis. To reveal this stalling mechanism we obtained 3.6-Å-resolution cryo-EM structur...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4935803/ https://ncbi.nlm.nih.gov/pubmed/27380950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12026 |
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