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Drug-Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation
During protein synthesis, nascent polypeptide chains within the ribosomal tunnel can act in cis to induce ribosome stalling and regulate expression of downstream genes. The Staphylococcus aureus ErmCL leader peptide induces stalling in the presence of clinically important macrolide antibiotics, such...
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| Udgivet i: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4252717/ https://ncbi.nlm.nih.gov/pubmed/25306253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.014 |
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