The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

Under stress conditions, such as nutrient starvation, deacylated tRNAs bound within the ribosomal A-site are recognized by the stringent factor RelA, which converts ATP and GTP/GDP to (p)ppGpp. The signaling molecules (p)ppGpp globally rewire the cellular transcriptional program and general metaboli...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Arenz, Stefan, Abdelshahid, Maha, Sohmen, Daniel, Payoe, Roshani, Starosta, Agata L., Berninghausen, Otto, Hauryliuk, Vasili, Beckmann, Roland, Wilson, Daniel N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2016
Ämnen:
Structural Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291266/
https://ncbi.nlm.nih.gov/pubmed/27226493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw470
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