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The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis
Under stress conditions, such as nutrient starvation, deacylated tRNAs bound within the ribosomal A-site are recognized by the stringent factor RelA, which converts ATP and GTP/GDP to (p)ppGpp. The signaling molecules (p)ppGpp globally rewire the cellular transcriptional program and general metaboli...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291266/ https://ncbi.nlm.nih.gov/pubmed/27226493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw470 |
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