Role of the (p)ppGpp Synthase RSH, a RelA/SpoT Homolog, in Stringent Response and Virulence of Staphylococcus aureus

In most bacteria, nutrient limitations provoke the stringent control through the rapid synthesis of the alarmones pppGpp and ppGpp. Little is known about the stringent control in the human pathogen Staphylococcus aureus, partly due to the essentiality of the major (p)ppGpp synthase/hydrolase enzyme...

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Bibliographic Details
Main Authors: Geiger, Tobias, Goerke, Christiane, Fritz, Michaela, Schäfer, Tina, Ohlsen, Knut, Liebeke, Manuel, Lalk, Michael, Wolz, Christiane
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863498/
https://ncbi.nlm.nih.gov/pubmed/20212088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01439-09
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