Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus

The stringent response is characterized by (p)ppGpp synthesis resulting in repression of translation and reprogramming of the transcriptome. In Staphylococcus aureus, (p)ppGpp is synthesized by the long RSH (RelA/SpoT homolog) enzyme, Rel(Sau) or by one of the two short synthetases (RelP, RelQ). RSH...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Gratani, Fabio Lino, Horvatek, Petra, Geiger, Tobias, Borisova, Marina, Mayer, Christoph, Grin, Iwan, Wagner, Samuel, Steinchen, Wieland, Bange, Gert, Velic, Ana, Maček, Boris, Wolz, Christiane
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053245/
https://ncbi.nlm.nih.gov/pubmed/29985927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007514
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