Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus

The stringent response is characterized by (p)ppGpp synthesis resulting in repression of translation and reprogramming of the transcriptome. In Staphylococcus aureus, (p)ppGpp is synthesized by the long RSH (RelA/SpoT homolog) enzyme, Rel(Sau) or by one of the two short synthetases (RelP, RelQ). RSH...

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Dades bibliogràfiques
Publicat a:PLoS Genet
Autors principals: Gratani, Fabio Lino, Horvatek, Petra, Geiger, Tobias, Borisova, Marina, Mayer, Christoph, Grin, Iwan, Wagner, Samuel, Steinchen, Wieland, Bange, Gert, Velic, Ana, Maček, Boris, Wolz, Christiane
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053245/
https://ncbi.nlm.nih.gov/pubmed/29985927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007514
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