Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

Regeneration of myelin is mediated by oligodendrocyte progenitor cells (OPCs), an abundant stem cell population in the CNS and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the central nervous system (CNS) underlies a number of neurological di...

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Udgivet i:Nature
Main Authors: Hubler, Zita, Allimuthu, Dharmaraja, Bederman, Ilya, Elitt, Matthew S., Madhavan, Mayur, Allan, Kevin C., Shick, H. Elizabeth, Garrison, Eric, Karl, Molly, Factor, Daniel C., Nevin, Zachary S., Sax, Joel L., Thompson, Matthew A., Fedorov, Yuriy, Jin, Jing, Wilson, William K., Giera, Martin, Bracher, Franz, Miller, Robert H., Tesar, Paul J., Adams, Drew J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423962/
https://ncbi.nlm.nih.gov/pubmed/30046109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0360-3
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