Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

Multiple sclerosis (MS) involves an aberrant autoimmune response and progressive failure of remyelination in the central nervous system (CNS). Prevention of neural degeneration and subsequent disability requires remyelination through the generation of new oligodendrocytes, but current treatments exc...

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Publicado no:Nature
Main Authors: Najm, Fadi J., Madhavan, Mayur, Zaremba, Anita, Shick, Elizabeth, Karl, Robert T., Factor, Daniel C., Miller, Tyler E., Nevin, Zachary S., Kantor, Christopher, Sargent, Alex, Quick, Kevin L., Schlatzer, Daniela M., Tang, Hong, Papoian, Ruben, Brimacombe, Kyle R., Shen, Min, Boxer, Matthew B., Jadhav, Ajit, Robinson, Andrew P., Podojil, Joseph R., Miller, Stephen D., Miller, Robert H., Tesar, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528969/
https://ncbi.nlm.nih.gov/pubmed/25896324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14335
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