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Diverse chemical scaffolds enhance oligodendrocyte formation by inhibiting CYP51, TM7SF2, or EBP

Small molecules that promote oligodendrocyte formation have been identified in ‘drug repurposing’ screens to nominate candidate therapeutics for diseases in which myelin is lost, including multiple sclerosis. We recently reported that many such molecules enhance oligodendrocyte formation not by thei...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Allimuthu, Dharmaraja, Hubler, Zita, Najm, Fadi J., Tang, Hong, Bederman, Ilya, Seibel, William, Tesar, Paul J., Adams, Drew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474808/
https://ncbi.nlm.nih.gov/pubmed/30773481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.01.004
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