UFL1 promotes histone H4 ufmylation and ATM activation

The ataxia-telangiectasia mutated (ATM) kinase, an upstream kinase of the DNA damage response (DDR), is rapidly activated following DNA damage, and phosphorylates its downstream targets to launch DDR signaling. However, the mechanism of ATM activation is still not completely understood. Here we repo...

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Udgivet i:Nat Commun
Main Authors: Qin, Bo, Yu, Jia, Nowsheen, Somaira, Wang, Minghui, Tu, Xinyi, Liu, Tongzheng, Li, Honglin, Wang, Liewei, Lou, Zhenkun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423285/
https://ncbi.nlm.nih.gov/pubmed/30886146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09175-0
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