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The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS
Human apolipoprotein B mRNA-editing catalytic polypeptide-like 3 proteins (APOBEC3s or A3s) are cytosine deaminases that protect cells by introducing promutagenic uraciles in invading retro-elements. However as a drawback of this protective activity, A3s can also target cellular DNA, leading to DNA...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6423136/ https://ncbi.nlm.nih.gov/pubmed/30886206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40941-8 |
| Oznake: |
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