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Mutating for Good: DNA Damage Responses During Somatic Hypermutation

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of antibodies. In this way SHM is key in optimizing antibody dependent immune responses. SHM is initiated by targeting the Acti...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Pilzecker, Bas, Jacobs, Heinz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423074/
https://ncbi.nlm.nih.gov/pubmed/30915081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00438
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