DNA polymerase θ contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

Somatic hypermutation of Ig variable region genes is initiated by activation-induced cytidine deaminase; however, the activity of multiple DNA polymerases is required to ultimately introduce mutations. DNA polymerase η (Polη) has been implicated in mutations at A/T, but polymerases involved in C/G m...

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Библиографические подробности
Главные авторы: Masuda, Keiji, Ouchida, Rika, Takeuchi, Arata, Saito, Takashi, Koseki, Haruhiko, Kawamura, Kiyoko, Tagawa, Masatoshi, Tokuhisa, Takeshi, Azuma, Takachika, O-Wang, Jiyang
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2005
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1236561/
https://ncbi.nlm.nih.gov/pubmed/16172387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505636102
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