Statins affect human glioblastoma and other cancers through TGF-β inhibition

The cholesterol-lowering statins have known anti-cancer effects, but the mechanisms and how to utilize statins in oncology have been unclear. We noted in the CellMiner database that statin activity against cancer lines correlated with higher expression of TGF-β target genes such as SERPINE1 and ZYX....

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Xiao, Aizhen, Brenneman, Breanna, Floyd, Desiree, Comeau, Laurey, Spurio, Kelsey, Olmez, Inan, Lee, Jeongwu, Nakano, Ichiro, Godlewski, Jakub, Bronisz, Agnieszka, Kagaya, Noritaka, Shin-ya, Kazuo, Purow, Benjamin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422202/
https://ncbi.nlm.nih.gov/pubmed/30899443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26733
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