Statins affect human glioblastoma and other cancers through TGF-β inhibition

The cholesterol-lowering statins have known anti-cancer effects, but the mechanisms and how to utilize statins in oncology have been unclear. We noted in the CellMiner database that statin activity against cancer lines correlated with higher expression of TGF-β target genes such as SERPINE1 and ZYX....

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Xiao, Aizhen, Brenneman, Breanna, Floyd, Desiree, Comeau, Laurey, Spurio, Kelsey, Olmez, Inan, Lee, Jeongwu, Nakano, Ichiro, Godlewski, Jakub, Bronisz, Agnieszka, Kagaya, Noritaka, Shin-ya, Kazuo, Purow, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422202/
https://ncbi.nlm.nih.gov/pubmed/30899443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26733
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