Combined CDK4/6 mTOR inhibition is synergistic against glioblastoma via multiple mechanisms

PURPOSE: Glioblastoma (GBM) is a deadly brain tumor marked by dysregulated signaling and aberrant cell cycle control. Molecular analyses have identified that the CDK4/6-Rb-E2F axis is dysregulated in about 80% of GBMs. Single-agent CDK4/6 inhibitors have failed to provide durable responses in GBM, s...

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Dettagli Bibliografici
Pubblicato in:Clin Cancer Res
Autori principali: Olmez, Inan, Brenneman, Breanna, Xiao, Aizhen, Serbulea, Vlad, Benamar, Mouadh, Zhang, Ying, Manigat, Laryssa, Abbas, Tarek, Lee, Jeongwu, Nakano, Ichiro, Godlewski, Jakub, Bronisz, Agnieszka, Abounader, Roger, Leitinger, Norbert, Purow, Benjamin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690820/
https://ncbi.nlm.nih.gov/pubmed/28814434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0803
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