SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes

Hypoxia-inducible factor 2α (HIF2α) directly regulates a battery of genes essential for intestinal iron absorption. Interestingly, iron deficiency and overload disorders do not result in increased intestinal expression of glycolytic or angiogenic HIF2α target genes. Similarly, inflammatory and tumor...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Ma, Xiaoya, Das, Nupur K., Castillo, Cristina, Gourani, Ayla, Perekatt, Ansu O., Verzi, Michael P., Shah, Yatrik M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422077/
https://ncbi.nlm.nih.gov/pubmed/30659096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005549
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