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Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity

Colorectal cancer (CRC) is the third-leading cause of cancer mortality in the United States and other industrialized countries. A hypoxic microenvironment is a hallmark for solid tumors. The hypoxia-induced signal transduction is transcriptionally mediated by hypoxia-inducible factor (HIF). Three ma...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ma, Xiaoya, Zhang, Huabing, Xue, Xiang, Shah, Yatrik M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641885/
https://ncbi.nlm.nih.gov/pubmed/28848049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805655
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