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Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE(2) signaling axis in colon cancer
Cyclooxygenase 2 (COX2) is overexpressed in 80% of colon adenocarcinomas. However, the mechanism leading to aberrant COX2 expression in tumors is unclear. Intestinal epithelium-specific disruption of the von Hippel–Lindau tumor suppressor protein (VHL) in adenomatous polyposis coli (Apc)(min/+) mice...
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Oxford University Press
2013
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3534191/ https://ncbi.nlm.nih.gov/pubmed/23042097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs313 |
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