Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factor (HIF), a heterodimer of HIF-α and the aryl hydrocarbon receptor nuclear translocator subunits. The HIF-1α and HIF-2α subunits are structurally similar in their DNA binding and dimerization domains but differ in t...

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Detalhes bibliográficos
Main Authors: Hu, Cheng-Jun, Wang, Li-Yi, Chodosh, Lewis A., Keith, Brian, Simon, M. Celeste
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC309606/
https://ncbi.nlm.nih.gov/pubmed/14645546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.24.9361-9374.2003
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