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Activation of HIF-1α does not increase intestinal tumorigenesis
The hypoxic response is mediated by two transcription factors, hypoxia-inducible factor (HIF)-1α and HIF-2α. These highly homologous transcription factors are induced in hypoxic foci and regulate cell metabolism, angiogenesis, cell proliferation, and cell survival. HIF-1α and HIF-2α are activated ea...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4101679/ https://ncbi.nlm.nih.gov/pubmed/24875099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00112.2014 |
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