HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron

Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis and confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated by the transcription factors hypoxia-inducible factor 1α (HIF-1α) and HIF-2α. Our work demonstrates that HIF-2α is esse...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Singhal, Rashi, Mitta, Sreedhar R., Das, Nupur K., Kerk, Samuel A., Sajjakulnukit, Peter, Solanki, Sumeet, Andren, Anthony, Kumar, Roshan, Olive, Kenneth P., Banerjee, Ruma, Lyssiotis, Costas A., Shah, Yatrik M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203462/
https://ncbi.nlm.nih.gov/pubmed/33914705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143691
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