Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload

Iron-related disorders are among the most prevalent diseases worldwide. Systemic iron homeostasis requires hepcidin, a liver-derived hormone that controls iron mobilization through its molecular target ferroportin (FPN), the only known mammalian iron exporter. This pathway is perturbed in diseases t...

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Udgivet i:J Clin Invest
Main Authors: Schwartz, Andrew J., Das, Nupur K., Ramakrishnan, Sadeesh K., Jain, Chesta, Jurkovic, Mladen T., Wu, Jun, Nemeth, Elizabeta, Lakhal-Littleton, Samira, Colacino, Justin A., Shah, Yatrik M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307944/
https://ncbi.nlm.nih.gov/pubmed/30352047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122359
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