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SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes
Hypoxia-inducible factor 2α (HIF2α) directly regulates a battery of genes essential for intestinal iron absorption. Interestingly, iron deficiency and overload disorders do not result in increased intestinal expression of glycolytic or angiogenic HIF2α target genes. Similarly, inflammatory and tumor...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6422077/ https://ncbi.nlm.nih.gov/pubmed/30659096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005549 |
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