Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

[Image: see text] Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the identification of previously unreported inhibitors of MqnE using a mechanism-guided approach. The best inhibitor shows...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Joshi, Sumedh, Fedoseyenko, Dmytro, Mahanta, Nilkamal, Ducati, Rodrigo G., Feng, Mu, Schramm, Vern L., Begley, Tadhg P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421580/
https://ncbi.nlm.nih.gov/pubmed/30891141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00649
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