Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions

In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F(420), and heme. Our focus is on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological ch...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Mehta, Angad P., Abdelwahed, Sameh H., Mahanta, Nilkamal, Fedoseyenko, Dmytro, Philmus, Benjamin, Cooper, Lisa E., Liu, Yiquan, Jhulki, Isita, Ealick, Steven E., Begley, Tadhg P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
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Minireviews
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326808/
https://ncbi.nlm.nih.gov/pubmed/25477515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R114.623793
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