Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions

In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F(420), and heme. Our focus is on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological ch...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mehta, Angad P., Abdelwahed, Sameh H., Mahanta, Nilkamal, Fedoseyenko, Dmytro, Philmus, Benjamin, Cooper, Lisa E., Liu, Yiquan, Jhulki, Isita, Ealick, Steven E., Begley, Tadhg P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Minireviews
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326808/
https://ncbi.nlm.nih.gov/pubmed/25477515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R114.623793
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