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Radical SAM Enzyme HydE Generates Adenosylated Fe(I) Intermediates En Route to the [FeFe]-Hydrogenase Catalytic H‑Cluster

The H-cluster of [FeFe]-hydrogenase consists of a [4Fe–4S](H)-subcluster linked by a cysteinyl bridge to a unique organometallic [2Fe](H)-subcluster assigned as the site of interconversion between protons and molecular hydrogen. This [2Fe](H)-subcluster is assembled by a set of Fe–S maturase enzymes...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Tao, Lizhi, Pattenaude, Scott A., Joshi, Sumedh, Begley, Tadhg P., Rauchfuss, Thomas B., Britt, R. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7440672/
https://ncbi.nlm.nih.gov/pubmed/32434327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c03802
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