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OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug
Drugs that reverse epigenetic silencing, such as the DNA methyltransferase inhibitor (DNMTi) 5-azacytidine (AZA), have profound effects on transcription and tumor cell survival. AZA is an approved drug for myelodysplastic syndromes and acute myeloid leukemia, and is under investigation for different...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6421468/ https://ncbi.nlm.nih.gov/pubmed/30814222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815071116 |
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