A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency

The oligoadenylate synthetase (OAS)–RNase L system is an IFN-inducible antiviral pathway activated by viral infection. Viral double-stranded (ds) RNA activates OAS isoforms that synthesize the second messenger 2-5A, which binds and activates the pseudokinase-endoribonuclease RNase L. In cells, OAS a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Daou, Salima, Talukdar, Manisha, Tang, Jinle, Dong, Beihua, Banerjee, Shuvojit, Li, Yize, Duffy, Nicole M., Ogunjimi, Abiodun A., Gaughan, Christina, Jha, Babal K., Gish, Gerald, Tavernier, Nicolas, Mao, Daniel, Weiss, Susan R., Huang, Hao, Silverman, Robert H., Sicheri, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547215/
https://ncbi.nlm.nih.gov/pubmed/32958664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006883117
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