OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug

Drugs that reverse epigenetic silencing, such as the DNA methyltransferase inhibitor (DNMTi) 5-azacytidine (AZA), have profound effects on transcription and tumor cell survival. AZA is an approved drug for myelodysplastic syndromes and acute myeloid leukemia, and is under investigation for different...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Banerjee, Shuvojit, Gusho, Elona, Gaughan, Christina, Dong, Beihua, Gu, Xiaorong, Holvey-Bates, Elise, Talukdar, Manisha, Li, Yize, Weiss, Susan R., Sicheri, Frank, Saunthararajah, Yogen, Stark, George R., Silverman, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421468/
https://ncbi.nlm.nih.gov/pubmed/30814222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815071116
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