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Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are ligand-activated nuclear receptors (NRs) that are notorious for their role in drug metabolism, causing unintended drug–drug interactions and decreasing drug efficacy. They control the xenobiotic detoxification system by...
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| 出版年: | Drug Discov Today |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6421094/ https://ncbi.nlm.nih.gov/pubmed/30731240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2019.01.021 |
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