Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

Arraying antigens in a multivalent nanoparticle form is often employed in vaccine design, but in vivo mechanisms underlying the enhanced immunity elicited by such vaccines remain poorly understood. Here we studied the fate of two different heavily glycosylated HIV antigens in protein nanoparticle or...

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Publicat a:Science
Autors principals: Tokatlian, Talar, Read, Benjamin J., Jones, Christopher A., Kulp, Daniel W., Menis, Sergey, Chang, Jason Y.H., Steichen, Jon M., Kumari, Sudha, Allen, Joel D., Dane, Eric L., Liguori, Alessia, Sangesland, Maya, Lingwood, Daniel, Crispin, Max, Schief, William R., Irvine, Darrell J.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420719/
https://ncbi.nlm.nih.gov/pubmed/30573546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat9120
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