Applications and limitations of fitting of the operational model to determine relative efficacies of agonists

Proper determination of agonist efficacy is essential in the assessment of agonist selectivity and signalling bias. Agonist efficacy is a relative term that is dependent on the system in which it is measured, especially being dependent on receptor expression level. The operational model (OM) of func...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Jakubík, Jan, Randáková, Alena, Rudajev, Vladimír, Zimčík, Pavel, El-Fakahany, Esam E., Doležal, Vladimír
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420642/
https://ncbi.nlm.nih.gov/pubmed/30874590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40993-w
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