Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death

Mutations of Fused in sarcoma (FUS), a ribonucleoprotein involved in RNA metabolism, have been found associated with both familial and sporadic cases of amyotrophic lateral sclerosis (ALS). Notably, besides mutations in the coding sequence, also mutations into the 3′ untranslated region, leading to...

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Publicado en:Sci Rep
Autores principales: Ajmone-Cat, Maria Antonietta, Onori, Angela, Toselli, Camilla, Stronati, Eleonora, Morlando, Mariangela, Bozzoni, Irene, Monni, Emanuela, Kokaia, Zaal, Lupo, Giuseppe, Minghetti, Luisa, Biagioni, Stefano, Cacci, Emanuele
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418113/
https://ncbi.nlm.nih.gov/pubmed/30872738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41040-4
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